PReS-FINAL-2018: The P53 gene polymorphisms and juvenile idiopathic arthritis
نویسندگان
چکیده
Introduction Juvenile idiopathic arthritis (JIA) is a multifactor chronic inflammatory joints disease that is characterized by long progressive course leading to the development of contractures and loss of joint function. Prediction of the likely outcomes and course of JIA is key approach of treatment. Currently, there are only several laboratory and radiological predictors of unfavorable prognosis of JIA. Reduced sensitivity of cells to apoptosis is one the possible mechanisms maintaining synovial inflammation in JIA. Polymorphisms Arg72Pro 4exon, ins/del16bp 3intron, G/C 6intron can determine activity of the P53 protein the key protein of intrinsic apoptosis pathway (P.Dumont et al 2003; A.Sallivan et al, A.Ghosh et al 2004).
منابع مشابه
Association of the polymorphisms P53 gene with juvenile idiopathic arthritis in children Russian Fedration
Methods We examined 58 children with juvenile idiopathic arthritis. Clinical, serological and x-ray manifestations were analyzed in children and correlated with the genotypes. For detection erosion bone process we used ultrasound, x-ray, MRI and diagnostic arthroscopy with synovial biopsy. We investigated (PCR-RFLP) the status of p53 gene this children with juvenile idiopathic arthritis and 100...
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